The pedigree shown below concerns a human disease known as familial hypercholesterolemia. This…

The pedigree shown below concerns a human disease known as familial hypercholesterolemia. This disorder is characterized by an elevation of serum cholesterol in the blood. Though relatively rare, this genetic abnormality can be a contributing factor to heart attacks. At the molecular level, this disease is caused by a defective gene that encodes a protein called low- density lipoprotein receptor (LDLR). In the bloodstream, serum cholesterol is bound to a carrier protein known as low-density lipoprotein (LDL). LDL binds to LDLR so that cells can absorb cholesterol. When LDLR is defective, it becomes more difficult for the cells to absorb cholesterol. This explains why the levels of LDL blood cholesterol remain high. Based on the pedigree, what is the most likely pattern of inheritance of this disorder

 

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